Gastrointestinal plasmacytoma presenting as gastrointestinal bleeding

Clin Lymphoma Myeloma. 2008 Oct;8(5):309-11. doi: 10.3816/CLM.2008.n.044.

Abstract

Clinical manifestations of gastrointestinal (GI) involvement in multiple myeloma (MM) are uncommon. We report a case of plasmacytoma presenting as upper GI bleeding in a patient with a known diagnosis of MM. Gastrointestinal bleeding persists despite aggressive medical and endoscopic treatment. The aim of our report is to heighten the awareness of plasmacytoma as an etiology of GI bleeding in patients with MM. Abnormal hemostasis, specifically the imbalance in function of all major components of the coagulation cascade, increasing bleeding risk in patients with MM, is also discussed.

Publication types

  • Case Reports

MeSH terms

  • Anemia
  • Colon / pathology*
  • Diagnosis, Differential
  • Gastrointestinal Diseases / diagnosis*
  • Gastrointestinal Diseases / pathology
  • Gastrointestinal Diseases / physiopathology*
  • Gastrointestinal Neoplasms / diagnosis*
  • Gastrointestinal Neoplasms / pathology
  • Gastrointestinal Neoplasms / physiopathology*
  • Hemorrhage / diagnosis*
  • Humans
  • Male
  • Melena
  • Middle Aged
  • Multiple Myeloma / pathology
  • Multiple Myeloma / physiopathology*
  • Neoplasms, Second Primary / diagnosis
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / physiopathology
  • Plasmacytoma / diagnosis*
  • Plasmacytoma / pathology
  • Plasmacytoma / physiopathology*
  • Time Factors