[Late-onset vaccination-induced subcutaneous pseudolymphoma]

Ann Pathol. 2008 Apr;28(2):146-9. doi: 10.1016/j.annpat.2007.11.004. Epub 2008 Jul 2.
[Article in French]

Abstract

Persistent subcutaneous nodules arise on rare occasions at sites of injection of aluminium hydroxide-adsorbed vaccine. We report a case following a diphtheria, tetanus and pertussis vaccination. The late onset of the lesion, four years after the injection, led to an uncertain preoperative diagnosis. Histopathologic examination showed features of a subcutaneous pseudolymphoma. The demonstration of aluminium by Morin staining and atomic absorption spectrometry on a paraffin-embedded tissue probe supported the diagnosis of a vaccination-induced pseudolymphoma.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aluminum
  • Coloring Agents
  • Diagnosis, Differential
  • Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
  • Female
  • Humans
  • Middle Aged
  • Pseudolymphoma / chemically induced*
  • Pseudolymphoma / pathology*
  • Skin Diseases / chemically induced*
  • Skin Diseases / pathology

Substances

  • Coloring Agents
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Aluminum