Vaccination granulomas and aluminium allergy: course and prognostic factors

Contact Dermatitis. 1992 May;26(5):304-6. doi: 10.1111/j.1600-0536.1992.tb00123.x.

Abstract

21 children who had cutaneous granulomas following immunization with a vaccine containing aluminium hydroxide, and who had positive patch tests to aqueous aluminium chloride and/or to a Finn Chamber, were followed for 1 to 8 years. During the period of observation, the symptoms cleared in 5 children, improved in 11, and remained unchanged in 5. The course of the granulomas could not be correlated with sex or atopy, nor with intensity of the initial aluminium patch test. 4 children were patch tested again with aluminium.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Aluminum / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Granuloma / chemically induced*
  • Granuloma / pathology
  • Humans
  • Male
  • Patch Tests
  • Prognosis
  • Skin Diseases / chemically induced*
  • Skin Diseases / pathology
  • Vaccination

Substances

  • Aluminum