Clinical—Alimentary TractInflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism
Section snippets
Study Design
The study was performed as a cohort study that included 2 cohorts. One cohort consisted of IBD patients with first VTE. This cohort was used to evaluate the rate and risk factors of recurrent VTE in IBD patients. The second cohort consisted of control patients with first VTE but without IBD. This cohort was used together with the first cohort for the comparison of recurrence rates of VTE between IBD and non-IBD patients. The acquisition of both cohorts will be described in detail here.29
IBD Patients
This
Patient Characteristics
One hundred and forty-two patients with DVT and/or PE after diagnosis of IBD were identified. Twenty-six patients were excluded because of ongoing anticoagulation, leaving 116 patients for further analysis. Table 1 shows the baseline characteristics of these patients. Anticoagulation was discontinued after a median time of 6.0 (interquartile range, 3.2−8.3) months. Median observation time after discontinuation of anticoagulation was 41.8 (interquartile range, 9.7−86.8) months. In 30 (25.9%)
Discussion
Our study shows that IBD patients are at high risk of recurrent thrombosis after a first VTE. Five years after discontinuation of anticoagulant treatment, the probability of recurrence was 29%. This rate was higher than in other studies of IBD patients, in which recurrence rates ranged between 13% and 21%.6, 7, 8 However, results of these former studies had been limited by small patient numbers and methodological shortcomings, including lack of objective diagnosis of first and recurrent VTE and
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This article has an accompanying continuing medical education activity on page e12. Learning Objective: Upon completion of this exercise, successful learners will be able to identify the risk of recurrent venous thromboembolism in patients with inflammatory bowel disease.
Conflicts of interest The authors disclose no conflicts.
Funding The study received funding through the Medical Scientific Fund of the Mayor of the City of Vienna (project number 2551) and the Hochschuljubiläumsstiftung of the City of Vienna (H-806/2005).