Original articleNeonatal Onset Intestinal Failure: An Italian Multicenter Study
Section snippets
Methods
A multicenter, nationwide, retrospective study was planned in collaboration with the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition and with the Italian Society of Neonatology. Clinical charts of all newborns observed in Italian tertiary center neonatal intensive care units (NICU) during the years 2003 and 2004 were reviewed. Participating centers were selected on the basis of reported characteristics: ability to take care of high-risk pregnancy and of critically ill
Results
The total number of live births in the 7 enrolled institutions was 30 353 newborns, and 5088 were admitted to the NICU. Twenty-six patients met the criteria for intestinal failure and were included in the study (gestational age: 32.0 weeks, IQR 27.7-35.2; birth weight: 1865.0 g, IQR: 867.5-2262.5). The occurrence rate of intestinal failure was 0.1% (1:1077) and 0.5% (1:196) considering all live-birth newborns and high-risk infants, respectively.
Main demographic and clinical characteristics are
Discussion
The average incidence of intestinal failure is a 1 in 200 NICU admission. Although improved technologies and expertise have led to better outcomes, complications of long-term PN such as progressive liver disease, sepsis, and loss of venous access still represent a major source of morbidity and death for PN-dependent infants. In this Italian cohort, the major underlying disorders leading to intestinal failure by congenital intestinal defects that require bowel surgery. Intestinal atresia and
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The authors declare no conflicts of interest.