Original articleCardiovascularRole of Surgery in the Treatment of Primary Pulmonary B-Cell Lymphoma
Section snippets
Material and Methods
We performed a computer search in our pathology database to identify patients with a biopsy-proven PPL operated on in our institution between 1985 and 2004. For all patients in the study cohort, an individual chart review was performed, with approval obtained from the Institutional Review Board, which waived the need for informed consent.
The diagnosis of PPL was based on characteristic histologic and immunophenotypical features according to the Kiel classification and the WHO classification [2
Results
We identified 17 patients (11 men, 6 women) fulfilling the criteria for PPL, with a median age of 60 years (range, 33 to 71 years). Pathologic diagnosis was low-grade B-cell PPL (MALT lymphoma) in 14 patients (82%; Fig 1) and high-grade B-cell lymphoma in 2 patients (11%; Fig 2). Lymphomatoid granulomatosis was observed in 1 patient. The mean follow-up was 4.3 years (range, 10 weeks to 15 years).
Comment
Primary pulmonary lymphomas are uncommon cancers arising from the lymphoreticular system of the lung and are estimated to occur in approximately 0.5% of all primary lung tumors [9]. They include solitary plasmocytoma, primary Hodgkin disease, and non-Hodgkin lymphoma of the lung. Primary pulmonary non-Hodgkin lymphoma is the most common PPL and is almost always of the B-cell type. B-cell PPL arises from bronchus-associated lymphoid tissue (BALT lymphoma) or from mucosa-associated lymphoid
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