Local bradykinin generation in hereditary angioedema☆,☆☆,★
Section snippets
METHODS
In 2 patients with acute forearm angioedema resulting from hereditary C1-inhibitor deficiency, we measured bradykinin in blood samples taken simultaneously from the edematous area and from the contralateral unaffected forearm. Plasma bradykinin was measured specifically by radioimmunoassay after liquid-phase extraction and subsequent high-performance liquid chromatography as recently described in detail.5 The detection limit was 0.2 fmol/mL. Both intra-assay and interassay coefficients of
RESULTS AND DISCUSSION
We found clearly increased concentrations of venous plasma bradykinin in the edematous forearm compared with the contralateral control arm (77 versus 9.5 fmol/mL and 46 versus 16 fmol/mL, respectively, with normal reference levels at 2.2 ± 2.2 fmol/mL) (Fig 1).
References (5)
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Kinin formation in hereditary angioedema plasma: evidence against kinin derivation from C2 and in support of “spontaneous” formation of bradykinin
J Allergy Clin Immunol
(1983) - et al.
Activation of the coagulation cascade in C1-inhibitor deficiencies
Blood
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Reprint requests: Angelo Agostoni, MD, Department of Internal Medicine, University of Milan, Via Pace, 15, 20122 Milan, Italy.
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J Allergy Clin Immunol 1999;104:1321-2.
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