Cell
ArticleCommitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis
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Editorial commentary: The cardiac regeneration interchange
2020, Trends in Cardiovascular MedicineThe use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin
2018, Pharmacological ResearchCitation Excerpt :Unfortunately, these shortcomings have been completely disregarded in the studies that purportedly have assessed CM turnover and the source of new CMs in adulthood (see below). As above stated, shortly after the post-natal period, CMs permanently withdraw from the cell cycle becoming terminally-differentiated cells [2]. Mature CMs indeed do not re-enter the cell cycle and in the very rare occasions they do, do not undergo mitosis but die by apoptosis [58].
Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery
2017, Pharmacology and TherapeuticsCitation Excerpt :However, the lack of cardiomyocyte differentiation capability of bone marrow cells or CSCs could be due to lack of characterisation of the transplanted cell type, poor cell survival and retention, hostile host environment and subsequent restriction of cell proliferation, integration and differentiation in this damage-regeneration infarct model. Despite the adult mammalian heart being composed of terminally differentiated cardiomyocytes that are permanently withdrawn from the cell cycle (Chien & Olson, 2002; Nadal-Ginard, 1978), it is now apparent that the adult heart has the capacity, albeit low, to self-renew cardiomyocytes over the human lifespan (Bergmann et al., 2012, 2015). This is supported by the detection of small, newly-formed, immature cardiomyocytes, which incorporate BrdU/EdU and/or stain positive for Ki67, Aurora B, and embryonic/neonatal myosin heavy chain, as well as cardiomyocytes undergoing mitosis, under normal conditions and in response to diverse pathological and physiological stimuli (Bergmann et al., 2015; Bostrom et al., 2010; Ellison et al., 2013; Urbanek et al., 2003, 2005; Waring et al., 2014).
The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult
2014, Stem Cell ResearchCitation Excerpt :It is clear now that the blood borne precursors, although documented as a biological phenomenon (Quaini et al., 2002; Eisenberg et al., 2006) might be limited to very special situations (Orlic et al., 2001) and their direct regenerative import is, if any, very limited (Loffredo et al., 2011). The mammalian myocardial response to increased workload and to injury is conditioned by the fact that, shortly after the post-natal period, CMs permanently withdraw from the cell cycle (Nadal-Ginard., 1978). The molecular mechanism of terminal differentiation in CMs has not yet been completely defined.