Skip to main content

Advertisement

Log in

Primary T-cell lymphoma of the thyroid: case report and review of the literature

  • CASE
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Here we report a rare case of primary T-cell lymphoma of the thyroid gland. A 32-year-old Chinese man was admitted to our hospital because of marked goiter and subcutaneous nodules. Computed tomography (CT) scan of the neck disclosed diffuse enlargement of the thyroid gland. A diagnosis of peripheral T-cell lymphoma was made according to cytopathological findings of fine-needle aspiration (FNA) of the thyroid gland and skin biopsy. Immunohistochemistry stain showed that the tumor was positive for CD3 and negative for CD20. Clonal T-cell receptor (TCR-γ) gene rearrangements were demonstrated by polymerase chain reaction. After six cycles of combination chemotherapy (bleomycin, cyclophosphamide, doxorubicin, vincristine, and prednisone), the thyroid retracted to normal size gradually.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ansell SM, Grant CS, Habermann TM. Primary thyroid lymphoma. Semin Oncol. 1999;26:316–23.

    PubMed  CAS  Google Scholar 

  2. Thieblemont C, Mayer A, Dumontet C, Barbier Y, Callet-Bauchu E, Felman P, Berger F, Ducottet X, Martin C, Salles G, Orgiazzi J, Coiffier B. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab. 2002;87:105–11.

    Article  PubMed  CAS  Google Scholar 

  3. Abdul-Rahman ZH, Gogas HJ, Tooze JA, Anderson B, Mansi J, Sacks NP, Finlayson CJ. T-cell lymphoma in Hashimoto’s thyroiditis. Histopathology. 1996;29:455–9.

    Article  PubMed  CAS  Google Scholar 

  4. Coltrera MD. Primary T-cell lymphoma of the thyroid. Head Neck. 1999;21:160–3.

    Article  PubMed  CAS  Google Scholar 

  5. Forconi F, Bocchia M, Marconcini S, Bigazzi C, Milani M, Fraternali-Orcioni G, Lauria F. CD30 positive (non-anaplastic) peripheral T-cell lymphoma of the thyroid gland. Haematologica. 1999;84:946–8.

    PubMed  CAS  Google Scholar 

  6. Haciyanli M, Erkan N, Yorukoglu K, Sagol O, Harmancioglu O. Primary non-Hodgkin’s T-cell lymphoma of the thyroid gland complicating Hashimoto’s thyroiditis: case report. Thyroid. 2000;10:717–20.

    Article  PubMed  CAS  Google Scholar 

  7. Mizukami Y, Michigishi T, Nonomura A, Nakamura S, Hashimoto T, Katsuda S, Otake S, Matsubara F. Primary lymphoma of the thyroid: a clinical, histological and immunohistochemical study of 20 cases. Histopathology. 1990;17:201–9.

    Article  PubMed  CAS  Google Scholar 

  8. Raftopoulos I, Vanuno D, Kouraklis G. Two unusual sites of colon cancer metastases and a rare thyroid lymphoma. Case 3. Primary T-cell lymphoma of the thyroid arising in a background of Hashimoto’s thyroiditis. J Clin Oncol. 2001;19:3576–80.

    PubMed  CAS  Google Scholar 

  9. Yamaguchi M, Ohno T, Kita K. gamma/delta T-cell lymphoma of the thyroid gland. New Engl J Med. 1997;336:1391–2.

    Article  PubMed  CAS  Google Scholar 

  10. Motoi N, Ozawa Y. Malignant T-cell lymphoma of the thyroid gland associated with Hashimoto’s thyroiditis. Pathol Int. 2005;55:425–30.

    Article  PubMed  Google Scholar 

  11. Colović M, Matić S, Kryeziu E, Tomin D, Colović N, Atkinson HD. Outcomes of primary thyroid non-Hodgkin’s Lymphoma: a series of nine consecutive cases. Med Oncol. 2007;24:203–8.

    Article  PubMed  Google Scholar 

  12. Koida S, Tsukasaki K, Tsuchiya T, Harasawa H, Fukushima T, Yamada Y, Ohshima K, Kamihira S, Kikuchi M, Tomonaga M. Primary T-cell lymphoma of the thyroid gland with chemokine receptors of Th1 phenotype complicating autoimmune thyroiditis. Haematologica. 2007;92:e37–40.

    Article  PubMed  Google Scholar 

  13. Okamoto A, Namura K, Uchiyama H, Kajita Y, Inaba T, Nakamura S, Shimazake C. Cytotoxic T-cell non-Hodgkin’s lymphoma of the thyroid gland. Am J Hematol. 2005;80:77–8.

    Article  PubMed  Google Scholar 

  14. Mizukami Y, Matsubara F, Hashimoto T, Terahata S, Ikuta N, Nakamura S, Ooi A. Primary T-cell lymphoma of the thyroid. Acta Pathol Jpn. 1987;37:1987–95.

    PubMed  CAS  Google Scholar 

  15. Freeman HJ. T cell lymphoma of the thyroid gland in celiac disease. Can J Gastroenterol. 2000;14:635–6.

    PubMed  CAS  Google Scholar 

  16. Peng H, Du M, Diss TC, Isaacson PG, Pan L. Genetic evidence for a clonal link between low and high-grade components in gastric MALT B-cell lymphoma. Histopathology. 1997;30:425–9.

    Article  PubMed  CAS  Google Scholar 

  17. Cha C, Chen H, Westra WH, Udelsman R. Primary thyroid lymphoma: can the diagnosis be made solely by fine-needle aspiration? Ann Surg Oncol. 2002;9:298–320.

    Article  PubMed  Google Scholar 

  18. Shimoyama M, Oyama A, Tajima K, Tobinai K, Minato K, Takenaka T, Konda C, Takeyama K, Kohno A, Narabayashi M, et al. Differences in clinicopathological characteristics and major prognostic factors between B-lymphoma and peripheral T-lymphoma excluding adult T-cell leukemia/lymphoma. Leuk Lymphoma. 1993;10:335–42.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jian Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, H., Li, J. & Shen, T. Primary T-cell lymphoma of the thyroid: case report and review of the literature. Med Oncol 25, 462–466 (2008). https://doi.org/10.1007/s12032-008-9059-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-008-9059-x

Keywords

Navigation