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Pneumatosis cystoides intestinalis: A pathophysiologic explanation of the roentgenographic signs

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Abstract

Pneumatosis intestinalis was first described by Du Vernoi in 1730. The roentgenographic, gross, and microscopic pathologic changes are secondary to noncommunicating gas-filled cysts which occur either in submucosa or subserosa. The clinical findings, roentgenologic signs, and treatment are discussed. A differential diagnosis and pathophysiologic explanation for the changes are presented.

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References

  1. Du Vernoi J: Anatomische Beobachtungen der unter der äußern und innern Haut der Gedärme cingeschlossenene Luft.Phys Med Abhandl Acad Wissensch Petersb 2: 182–188, 1783.

    Google Scholar 

  2. Meyer A: Pneumatosis cystoides intestinorum.J Prac Heilk 61: 67. 1925.

    Google Scholar 

  3. Lerner H, Gazin E: Pneumatosis intestinalis: its roentgenologic diagnosis.Am J Roentgenol Radium Ther Nucl Med 56: 464–469, 1946.

    Google Scholar 

  4. Mujahed Z, Evans J: Gas cysts of the intestine (pneumatosis intestinalis).Surg Gynecol Obstet 107: 151–160, 1958.

    Google Scholar 

  5. Bockus H:Gastroenterology, Vol. 2. Philadelphia, WB Saunders Co, 1964, pp 219–225.

    Google Scholar 

  6. Marshak R, Blum S, Eliasoph J: Pneumatosis involving the left side of the colon.JAMA 161: 1626–1628. 1956

    Google Scholar 

  7. Ecker J, Williams R, Clay K: Pneumatosis cystoides intestinalis-bullous emphysema of the intestine. A review of the literature.Am J Gastroenterol 56: 125–136, 1971.

    Google Scholar 

  8. Shallal J, van Heerden J, Bartholomew L, Cain J: Pneumatosis cystoides intestinalis.Mayo Clin Proc 49: 180–184, 1974.

    Google Scholar 

  9. Varano V, Bonanno C: Colonoscopic findings in pneumatosis cystoides intestinalis.Am J Gastroenterol 59: 353–360, 1973.

    Google Scholar 

  10. Reyna R, Soper R, Condon R: Pneumatosis intestinalis: report of twelve cases.Am J Surg 125: 667–671, 1973.

    Google Scholar 

  11. Koss L: Abdominal gas cysts (pneumatosis cystoides intestinorum hominis).Arch Pathol 53: 523–549, 1952.

    Google Scholar 

  12. MacKenzie E: Pneumatosis intestinalis: review of the literature and report of 13 cases.Pediatrics 7: 537–549, 1951.

    Google Scholar 

  13. Nelson S: Extraluminal gas collections.Am J Roentgenol. Radium Ther Nucl Med 115: 225–248, 1972.

    Google Scholar 

  14. Kushlan S: Pneumatosis cystoides intestinalis: report of a case mimicking the irritable bowel syndrome with x-ray diagnosis and resolution.JAMA 179: 699–702, 1962.

    Google Scholar 

  15. Bryk D: Unusual causes of small-bowel pneumatosis: perforated duodenal ulcer and perforated jejunal diverticula.Radiology 106: 299–302, 1973.

    Google Scholar 

  16. Seaman W, Fleming R, Baker D: Pneumatosis intestinalis of the samll bowel.Sem Roentgenol 1: 234–242, 1966.

    Google Scholar 

  17. Ecker J, Doane W, Dickson D: Diffuse familial polyposis of the colon: review of the literature and report of a case.Am J Gastroenterol 35: 127–137, 1961.

    Google Scholar 

  18. Forgacs P, Wright P, Wyatt A: Treatment of intestinal gas cysts by oxygen breathing.Lancet 1: 579–582, 1973

    Google Scholar 

  19. Down R, Castleden W: Oxygen therapy for pneumatosis coli.Br Med J 1: 493–494, 1975.

    Google Scholar 

  20. Höflin F, Van Der Linden W: Pneumatosis cystoides intestinalis treated by oxygen breathing.Scand J Gastroenterol 9: 427–430, 1974.

    Google Scholar 

  21. Keyting W, McCarver R, Kovarik J, et al.: Pneumatosis intestinalis: a new concept.Radiology 76: 733–741, 1961.

    Google Scholar 

  22. Killian H:Pneumopathien Neue Deutsche Chirurgie. Vol 60. Stuttgart. Ferdinand Enke Verlag. 1939.

    Google Scholar 

  23. Alford J, Galletti G, Culver G: Pneumatosis cystoides intestinalis.Am J Surg 92: 648–656, 1956.

    Google Scholar 

  24. Yale C, Balish E, Wu J: The bacterial etiology of pneumatosis cystoides intestinalis.Arch Surg 109: 89–94. 1974.

    Google Scholar 

  25. Borns P, Johnston T: Indolent pneumatosis of bowel wall associated with immune suppressive therapy.Ann Radiol 16: 163–166, 1973.

    Google Scholar 

  26. Oliveros M, Herbst J, Lester P, Ziter F: Pneumatosis intestinalis in childhood dermatomyositis.Pediatrics 52: 711–712, 1973.

    Google Scholar 

  27. Robinson A, Grossman H, Brumley G: Pneumatosis intestinalis in the neonate.Am J Roentgenol Radium Ther Nucl Med 120: 333–341, 1974.

    Google Scholar 

  28. Sticnnon O: Pneumatosis intestinalis in the newborn.Am J Dis Child 81: 651–661, 1951.

    Google Scholar 

  29. Lee S, Kuhn J: Pneumatosis intestinalis following pneumome-diastinum in a newborn infant.J Pediatr 79: 813–815, 1971.

    Google Scholar 

  30. Coello-Ramirez P, Gutierres-Topete G, Lifshitz F: Pneumatosis intestinalis.Am J Dis Chil 120: 3–9: 1970.

    Google Scholar 

  31. Aziz E: Neonatal pneumatosis intestinalis associated with milk intolerance.Am J Dis Chil 125: 560–562, 1973.

    Google Scholar 

  32. Keats T, Smith T: Benign pneumatosis intestinalis in childhood leukemia.Am J Roentgenol Radium Ther Nucl Med 122: 150–152, 1974.

    Google Scholar 

  33. Mueller C, Morehead R, Alter A, Michener W: Pneumatosis intestinalis in collagen disorders.Am J Roentgenol Radium Ther Nucl Med 115: 300–305, 1972.

    Google Scholar 

  34. Doub H, Shea J: Pneumatosis cystoides intestinalis.JAMA 172: 1238–1241, 1960.

    Google Scholar 

  35. Wood R, Herman C, Johnson K, di Sant'Agnese P: Pneumatosis coli in cystic fibrosis.Am J Dis Child 129: 246–248, 1975.

    Google Scholar 

  36. Freiman D, Chon H, Bilaniuk L: Pneumatosis intestinalis in systemic lupus erythematosus.Radiology 116: 563–564, 1975.

    Google Scholar 

  37. Druckman A, Schwartz A, Rabinovici N, et al.: Pneumatosis of the intestines.Am J Roentgenol Radium Ther Nucl Med 86: 911–919, 1961.

    Google Scholar 

  38. Colquhoun J: Intramural gas in hollow viscera.Clin Radiol 16: 71–86, 1965.

    Google Scholar 

  39. Ghahremani G, Port R, Beachley M: Pneumatosis coli in Crohn's disease.Dig Dis 19: 315–323, 1974.

    Google Scholar 

  40. Tomchik F, Wittenberg J, Ottinger L: The roentgenographic spectrum of bowel infarction.Radiology 96: 249–260, 1970.

    Google Scholar 

  41. Shuck J, Malan L, Hammar M: Pneumatosis cystoides intesttinalis due to blunt abdominal trauma.J Trauma 14: 435–440, 1974.

    Google Scholar 

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Address reprint requests to: Department of Radiologic Pathology, Armed Forces Institute of Pathology. Washington, D.C. 20306, U.S.A.

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Olmsted, W.W., Madewell, J.E. Pneumatosis cystoides intestinalis: A pathophysiologic explanation of the roentgenographic signs. Gastrointest Radiol 1, 177–181 (1976). https://doi.org/10.1007/BF02256362

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