Abstract
A chronic delayed hypersensitivity reaction was produced in the pig stomach. In skin-sensitized animals 2–4 dinitrochlorobenzene (DNCB) in adhesive paste produced mucosal ulceration with intestinalization, edema, and marked round-cell infiltration of the submucosa, vascular congestion, perivascular cuffing, and fibrinoid arteriolar changes. When pigs that were not skin-sensitized were given DNCB in adhesive paste, no mucosal ulceration was seen. A similar but less intense cellular infiltrate and vascular change was present. Circulating antibodies to DNCB showed no relationship to the morphological lesion, while parietal cell antibody immunofluorescent titers parallel the intensity of the tissue response. Under the conditions of this experiment, parietal cell antibodies are not involved in the pathogenesis of the mucosal lesion.
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We wish to acknowledge gratefully the assistance of Dr. H. Bernhardt for the immunofluorescent studies of parietal cell antibodies and we appreciate the devoted assistance of Dr. Wolcott Dunham, James Banks, and the staff of the Medical-Surgical Research Laboratories.
Supported by Grant 09384 of the NIH, US Public Health Service.
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Bicks, R.O., Azar, M.M., Bale, G.F. et al. Delayed hypersensitivity reactions in the intestinal tract. Digest Dis Sci 14, 385–393 (1969). https://doi.org/10.1007/BF02239356
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DOI: https://doi.org/10.1007/BF02239356