BMJ Case Reports 2018; doi:10.1136/bcr-2018-227574
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Dermatomyositis with anti-TIF1-γ antibodies

  1. Marie Baeck1
  1. 1Dermatology, Cliniques universitaires Saint-Luc, Bruxelles, Belgium
  2. 2Medecine Interne, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
  1. Correspondence to Dr Halil Yildiz, halil.yildiz{at}
  • Accepted 16 September 2018
  • Published 7 October 2018


We report the case of a 61-year-old Turkish male patient who presented to our dermatology outpatient clinic with a 1-year history of swelling and pruritic erythema rash of the face and trunk. He reported associated myalgia and arthralgia of the knees and wrists. Two months before presentation, he developed muscle weakness of upper limbs and dyspnoea. On review, he was noted to have unintentional weight loss (5 kg over 2 months) and increasing fatigue. His medical and family histories were unremarkable. His medications included omeprazole daily and vitamin B12 injections. Prior to presentation to our clinic, his general practitioner treated the patient with antihistamines, topical steroids (Elocom) and a short course of oral corticosteroid therapy which only provided temporary relief. Laboratory data demonstrated C reactive protein 6 mg/L (normal value (NV) <5 mg/L), haemoglobin 11.9 g/dL (NV 13–18 g/dL), lactate dehydrogenase 467 U/L (NV 135–225 U/L), creatinine phosphokinase 295 U/L (NV 30–190 U/L), Aspartate transaminase (GOT) 75 U/L (NV 8–31 U/L), Glutamate pyruvate transaminase (GPT) 66 U/L (NV 5–31 U/L); white blood count, ionogram, lipid profile, renal function, thyroid …

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