BMJ Case Reports 2018; doi:10.1136/bcr-2018-226818
  • Rare disease

Case of keratoacanthoma centrifugum marginatum treated with acitretin

  1. Sonal Shankar
  1. Department of Dermatology, Medway NHS Foundation Trust, Gillingham, UK
  1. Correspondence to Dr Sarah Helen Mehrtens, smehrtens{at}
  • Accepted 15 October 2018
  • Published 1 November 2018


Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterised by a progressively expanding tumour with a lack of spontaneous remission and significant scarring. KCM has been reported previously in less than 50 cases worldwide. We present the case of a large solitary KCM on the right shin of a 71-year-old woman. This was treated successfully with oral acitretin for 16 months with sustained remission at 24 months. Our case provides further supporting evidence for acitretin as a useful treatment for KCM to induce remission, prevent extensive surgery and minimise destructive scarring.


  • Contributors SHM wrote the manuscript, treated the patient and obtained consent. IdlH was the primary physician and revised the manuscript. SS treated the patient and revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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