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BMJ Case Reports 2018; doi:10.1136/bcr-2018-226316
  • Rare disease
  • CASE REPORT

Adult testicular granulosa cell tumour: an extremely rare entity

  1. Avelino Fraga1,3,2
  1. 1Urology Department, Centro Hospitalar do Porto, Porto, Portugal
  2. 2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
  3. 3Tumor Microenvironment and Interactions, i3S/INEB, Universidade do Porto, Porto, Portugal
  1. Correspondence to Mr Diogo Nunes-Carneiro, diogocarneiro.urologia{at}chporto.min-saude.pt
  • Accepted 13 October 2018
  • Published 1 November 2018

Summary

Adult granulosa cell tumours are extremely rare and usually benign but sometimes can assume an aggressive behaviour. A 31-year-old man presented with a 45 mm testicular mass. Radical orchiectomy was performed. Histological examination showed elongated cells, with hyperchromatic nuclei and Call-Exner bodies. Immunohistochemical analysis revealed positivity to vimentin, inhibin and negative PLAP and AE1/AE3 staining. The patient did not receive any adjuvant therapy and remained asymptomatic during 10 years. There are few cases of adult granulosa cell tumours and there is no consensus regarding malignancy criteria, treatment and follow-up. The description of these entities is crucial to allow a better management of these patients.

Footnotes

  • Contributors DN-C: acquisition of data, reporting, conception and design. AM-P: design. VC: discuss planing and interpretation of data. AF: discuss planing and interpretation of data.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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