BMJ Case Reports 2018; doi:10.1136/bcr-2018-226316
  • Rare disease

Adult testicular granulosa cell tumour: an extremely rare entity

  1. Avelino Fraga1,3,2
  1. 1Urology Department, Centro Hospitalar do Porto, Porto, Portugal
  2. 2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
  3. 3Tumor Microenvironment and Interactions, i3S/INEB, Universidade do Porto, Porto, Portugal
  1. Correspondence to Mr Diogo Nunes-Carneiro, diogocarneiro.urologia{at}
  • Accepted 13 October 2018
  • Published 1 November 2018


Adult granulosa cell tumours are extremely rare and usually benign but sometimes can assume an aggressive behaviour. A 31-year-old man presented with a 45 mm testicular mass. Radical orchiectomy was performed. Histological examination showed elongated cells, with hyperchromatic nuclei and Call-Exner bodies. Immunohistochemical analysis revealed positivity to vimentin, inhibin and negative PLAP and AE1/AE3 staining. The patient did not receive any adjuvant therapy and remained asymptomatic during 10 years. There are few cases of adult granulosa cell tumours and there is no consensus regarding malignancy criteria, treatment and follow-up. The description of these entities is crucial to allow a better management of these patients.


  • Contributors DN-C: acquisition of data, reporting, conception and design. AM-P: design. VC: discuss planing and interpretation of data. AF: discuss planing and interpretation of data.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article