BMJ Case Reports 2018; doi:10.1136/bcr-2018-226134
  • Unexpected outcome (positive or negative) including adverse drug reactions

Isoniazid-induced pure red cell aplasia

  1. Sitamahalakshminagasai Yerramsetti
  1. Department of Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, India
  1. Correspondence to Dr Basavaprabhu Achappa, bachu1504{at}
  • Accepted 25 September 2018
  • Published 7 October 2018


The pure red cell aplasia (PRCA) is an uncommon side effect of isoniazid. We describe a 28-year-old man who developed a severe anaemia caused by PRCA. The patient received antituberculous therapy including isoniazid for his pulmonary tuberculosis. On discontinuation of isoniazid, the anaemia recovered promptly. PRCA should be considered in case of unexplained anaemia during isoniazid treatment.


  • Contributors SY collected the data regarding the patient. SKH was involved in the manuscript writing and design. BA was involved in drafting, editing and revising the article. PMR was involved in the interpretation of data. All authors discussed the results and contributed to the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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