You are here

Article Text

Article menu

This article has a correction. Please see:

Download PDFPDF

XML
Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
CASE REPORT
Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection
  1. Lotte Ebdrup1,
  2. Kirk Druey2,
  3. Trine Hyrup Mogensen1,3,4
  1. 1Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
  2. 2Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
  3. 3Department of Biomedicine, Aarhus University, Aarhus, Denmark
  4. 4Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
  1. Correspondence to Professor Trine Hyrup Mogensen, trine.mogensen{at}biomed.au.dk

Summary

Systemic capillary leak syndrome (SCLS), also known as Clarkson syndrome, is a rare disease with potential fatal outcome. The clinical picture involves leakage of fluid and protein from the bloodstream into peripheral tissues, resulting in hypoalbuminaemia, elevated haematocrit, oedema and hypotension. The spectrum of the symptoms ranges from discrete swelling/oedema of extremities to fulminant cardiogenic shock. We present a case with a 52-year-old man diagnosed with SCLS after being resuscitated from cardiac arrest, which was complicated by compartment syndrome. The severe episode of capillary leak was potentially triggered by influenza virus infection. With the benefit of hindsight, he presented with symptoms of SCLS 2 years prior the major acute episode. Here we describe this case and review some aspects of the literature on SCLS, with particular focus on the pathogenesis, treatment/prophylaxis and long-term physical and psychological complications.

  • influenza
  • immunology
  • monoclonal gammopathy of undetermined significance associated neuropathy
  • heart failure

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bcr-2018-226108

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors LE and THM diagnosed and cared for the patient. KD performed a second opinion evaluation of the patient and advised on follow-up and prophylactic treatment. THM drafted the first version of the manuscript; all authors read and approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    Linked Articles