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Rare disease
CASE REPORT
Primary intracranial leiomyosarcoma among patients with AIDS in the era of new chemotherapeutic and biological agents
  1. Christian N Francisco1,
  2. Marissa Alejandria1,
  3. Edsel Maurice Salvaña1,
  4. Vida Margarette de Vera Andal2
  1. 1Department of Medicine, Section of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  2. 2Department of Neurosciences, Philippine General Hospital, Manila, Philippines
  1. Correspondence to Dr Christian N Francisco, christianfrancisco1{at}gmail.com

Summary

Primary intracranial leiomyosarcoma (PIL) is a rare non-infectious aetiology of focal mass lesions among HIV-infected individuals. With only 16 published cases worldwide, information on its pathophysiology, risk factors, clinical course and management options is limited. We report two cases of PIL in HIV-infected Filipino men who presented with 1–3 months history of persistent headache, progressing in severity. Both had cranial MRI revealing intracranial mass diagnosed as leiomyosarcoma by excision biopsy and immunohistochemical staining. Both patients underwent adjuvant cranial radiotherapy and chemotherapy. Biologics were initiated in one patient. Both patients were alive with evidence of the disease.

  • Hiv / Aids
  • neurooncology

https://doi.org/10.1136/bcr-2018-225714

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    Footnotes

    • Contributors CNF took part in patient data acquisition, involved in the planning and design of the report, writing of the manuscript, review of related literature, analysis of data and approval of the final manuscript. MA was involved in patient data acquisition, planning in the concept of the report, analysis of data, review of related literature, editing the manuscript and approval of the final manuscript. EMS was involved in patient data acquisition, analysis of data and approval of final manuscript. VMdVA was involved in patient data acquisition, planning and design of the report and approval of the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.