BMJ Case Reports 2018; doi:10.1136/bcr-2018-225576
  • Unusual association of diseases/symptoms

Anaplastic large cell lymphoma in a pregnant Filipino woman successfully treated with prepartum and postpartum chemotherapy

  1. Jorge Ignacio1
  1. 1Section of Medical Oncology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  2. 2Section of Perinatology, Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  1. Correspondence to Dr Madelaine Amurao Amante, madelaine_amurao{at}; maamante{at}
  • Accepted 23 August 2018
  • Published 12 September 2018


Diagnosis of a malignancy during pregnancy presents a dilemma regarding the work-up and treatment of the patient. This report presents a 42-year-old woman on her 23rd week of pregnancy with multiple enlarging fungating violaceous skin masses. Biopsy of the dominant mass revealed anaplastic large cell lymphoma. Due to the progressive enlargement and increase in number of the masses, the patient was given two cycles of chemotherapy (doxorubicin, vincristine, cyclophosphamide and prednisone) before delivering a live baby boy via spontaneous vaginal delivery, Apgar 9.9, at 37 4/7 weeks. After delivery, she completed four more cycles of treatment. A full-body positron emission tomography scan done 2 months after the last chemotherapy showed no evidence of disease. The patient is doing well with no evidence of disease 9 months after treatment. Her baby is thriving and has no gross deformities and no developmental delays.


  • Contributors MAA: the main author of this paper, led the oncological management of the patient, planned the writing of this paper, coordinated with the patient, secured consent and led the writing and final revision of the paper. SJPG: the perinatologist who cared for the patient during the treatment, had major contribution in the planning and writing, as well as revision of this paper. JI: the advisor of the authors provided critical insight in care of the patient, as well as the writing, revision and final approval of this paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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