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A 61-year-old single man with three children and a history of epididymo-orchitis and urethral stenosis 2 years earlier had suffered from bone pain for 3 months. The pain was disabling and affected the legs, pelvis and forearms. He had neither fever nor asthenia but had lost 8 kg. He was treated with paracetamol and tramadol with poor improvement. Then a discrete maculopapular rash of the trunk appeared, initially suggesting a drug reaction. At admission to hospital 6 months after the onset of the symptoms, the patient reported multiple bisexual relationships for about 2 years. There were slight painful indurations of the tibial crests and slightly infiltrated coppery palmoplantar papules with a thin squamous rim (figure 1), without any other clinical abnormality.
X-ray and CT scan revealed cortical osteolysis associated with periosteal reactions in the two tibias, the sternal manubrium, the 7th and 11th left ribs and both radius and ulnas (figures 2 and 3). Bone marrow puncture and protein electrophoresis were normal. Syphilis serology was positive with Treponema Pallidum Hemagglutinations Assay (TPHA) at 1/20 480 and Venereal Disease Research Laboratory (VDRL) at 1/16. Hepatitis and HIV serology were negative. Cerebrospinal fluid examination was normal. Penicillin-G treatment 4 MIUx6/day was initiated for 15 days, and bone pain resolved within 7 days. Three months later, bone CT scan showed an almost total resolution of the bone lesions.
Syphilis is a sexually transmitted disease with a wide variety of symptoms. Its incidence has been rising since 2000 in many countries, as in the USA (from 2.1 to 8.7/100 000 between 2000 and 2016). Syphilis mainly affects men who have sex with men, often HIV infected (47%1). Secondary syphilis may concern many organs, but very rarely the bone, with only 37 cases reported in 49 years. The most frequently affected bones were long bones of the limbs (60%), the skull (57%) and ribs (14%).2 To observe spirochetes on bone biopsy is erratic. Indeed, only five cases were associated with the presence of a micro-organism in the biopsy, never by using the same technique2: either dark-field microscope, silver or immunoperoxidase staining or PCR. Histopathology examination usually finds plasmacytic infiltration.
X-rays typically show multifocal bone destruction and sometimes periostitis. Differential radiological diagnoses include multiple myeloma, cancer, bone metastatic lesions, amyloidosis, sarcoidosis, tuberculosis and Paget’s disease.3 Yaws has a similar radiological aspect of polyosteoperiostitis but localised rather in the feet and hands and usually more severe than in syphilis.
This case was treated as tertiary syphilis, because the bone involvement was severe. Moreover, treatment data on the efficacy of intramuscular penicillin G for syphilitic bone lesions are limited.3
In conclusion, bone syphilis is relatively easy to diagnose with serological tests and also easy to treat with penicillin G. The main challenge is now to evocate such a diagnosis, in particular in front of unexplained bone pain in patients with at-risk sexual intercourses.
Learning points
Early syphilis, as the great imitator, can induce multifocal bone destruction and periostitis causing bone pain.
Unexplained bone pain may discuss syphilis in patients with at-risk sexual intercourses.
Footnotes
Contributors All authors managed the case and reviewed the manuscript. J-CC and LP wrote the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.