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Unexpected outcome (positive or negative) including adverse drug reactions
CASE REPORT
Mycophenolate mofetil-induced colitis in a patient with systemic sclerosis
  1. Gianluca Moroncini1,2,
  2. Devis Benfaremo1,2,
  3. Alessandra Mandolesi3,
  4. Armando Gabrielli1,2
  1. 1Dipartimento Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy
  2. 2Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy
  3. 3Anatomia Patologica, AOU Ospedali Riuniti di Ancona, Ancona, Italy
  1. Correspondence to Gianluca Moroncini, g.moroncini{at}univpm.it

Summary

We present the case of a 44-year-old woman affected by systemic sclerosis (SSc) who was admitted to our department for abdominal pain, nausea, vomiting and fever. Imaging studies showed the presence of a thickened colon wall involving the descending colon and the sigma, while a subsequent endoscopy revealed multiple serpiginous ulcers covered with fibrin and exudates. Under the hypothesis of drug-induced colitis, mycophenolate mofetil (MMF), which she was taking for SSc-related interstitial lung disease (ILD), was readily suspended, with a rapid recovery without further treatment. A follow-up colonoscopy showed the complete resolution of the ulcers. This is the first case of MMF-induced colitis in a patient being treated for SSc-ILD.

  • connective tissue disease
  • musculoskeletal and joint disorders
  • inflammatory bowel disease

https://doi.org/10.1136/bcr-2018-224829

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    Footnotes

    • Contributors GM, DB and AG took care of the patient during the course of the disease. AM reviewed the histological specimen and contributed to the diagnosis. GM and DB wrote the manuscript. AG reviewed the final draft of the manuscript. All authors approved the final version.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.