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  • Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome

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Unusual presentation of more common disease/injury
CASE REPORT
Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome
  1. Lindsay A Sobotka1,
  2. Ahmad Malli2,
  3. Wei Chen3,
  4. Khalid Mumtaz2
  1. 1Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio, USA
  2. 2Department of Gastroenterology, Hepatology and Nutrition, The Ohio State Wexner Medical Center, Columbus, Ohio, USA
  3. 3Department of Pathology, The Ohio State Wexner Medical Center, Columbus, Ohio, USA
  1. Correspondence to Dr Khalid Mumtaz, khalid.mumtaz{at}osumc.edu

Summary

Liver involvement by acute leukaemia is rare and has a high mortality rate despite treatment. We report a case of a 66-year-old woman undergoing treatment for myelodysplastic syndrome with Vidaza (azacitidine) who presented with abnormal liver function tests. Despite negative serologic testing and unremarkable abdominal MRI, she continued to have significant elevation in bilirubin and international normalised ratio and worsening mental status. Liver biopsy was obtained and consistent with acute myelogenous leukaemia. The patient had rapid demise due to acute liver failure and was unable to undergo treatment.

  • liver disease
  • haematology (incl blood transfusion)

https://doi.org/10.1136/bcr-2018-224590

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    Footnotes

    • Contributors LAS, AM, WC and KM drafted the manuscript and edited for intellectual content. All authors participated equally.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Next of kin consent obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.