BMJ Case Reports 2018; doi:10.1136/bcr-2018-224512
  • Unusual presentation of more common disease/injury

Spontaneous tumour lysis syndrome in small cell lung cancer: a rare phenomenon

  1. Mukta Sharma1
  1. 1 Internal Medicine, Michigan State University, East Lansing, Michigan, USA
  2. 2 Department of Pathology, Sparrow Hospital, Lansing, Michigan, USA
  1. Correspondence to Dr Manoj P Rai, manoj.rai{at}
  • Accepted 29 May 2018
  • Published 13 June 2018


Tumour lysis syndrome (TLS) is an oncological emergency. It is caused by cellular death occurring secondary to cancer therapy or spontaneously in rapidly dividing tumours. More common in haematological malignancies, it has also been reported in solid tumours. Out of 14 cases of small cell lung cancer (SCLC) with TLS, only three cases of spontaneous TLS have been reported in literature to date. Here we report a case of SCLC presenting as a spontaneous TLS.


  • Contributors PD wrote the case description, discussion and revised the manuscript. MPR contributed to the introduction, discussion and learning points. MT provided description on the pathology slides. MS revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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