BMJ Case Reports 2018; doi:10.1136/bcr-2018-224419
  • Unusual presentation of more common disease/injury

Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma

Open Access
  1. Steven Raymond Miller3
  1. 1School of Medicine, Wayne State University, Detroit, Michigan, USA
  2. 2Department of Oncology, Wayne State University, Detroit, Michigan, USA
  3. 3Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
  1. Correspondence to Dr Steven Raymond Miller, srmiller{at}
  • Accepted 15 October 2018
  • Published 1 November 2018


A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. After surgery, adjuvant radiation therapy was directed to the residual disease. The patient eventually relapsed in other sites not including the right atrium and eventually succumbed to her disease.


  • Contributors AW was responsible for gathering the patient data, reviewing the pertinent articles related to the topic under supervision of SM and MJ, as well as a major contributor to the writing of the paper. MJ provided knowledge and guidance of the biology underlying the treatment as well as assistance in the writing and editing of the paper. SM is the senior author as well as the physician who developed the treatment plan for this patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

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