BMJ Case Reports 2018; doi:10.1136/bcr-2018-224229
  • Images in…

Ichthyosis: A Harbinger of Lymphoma

  1. Pankaj Malhotra1
  1. 1Department of Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  2. 2Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr Kundan Mishra, mishrak20{at}
  • Accepted 16 March 2018
  • Published 10 April 2018


A 60-year-old, previously healthy woman presented with patchy skin colour change and dryness for 3 months duration. She also gave a history of recurrent boils requiring local and oral antibiotics. On examination, patchy hyperpigmented skin with scaly appearance was apparent along with features of healed and active infection (figure 1). She also had multiple, firm, lymph nodes (largest 2 cm) in the bilateral axillae. On evaluation, haemoglobin was 115 g/L, white blood cells 7.8×109/L, platelets 248×109/L; peripheral blood smear was normal. Representative skin biopsy showed loss of granular layer characteristic of ichthyosis (figure 2). Right axillary lymph node excision biopsy and immunohistochemistry confirmed …

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