Article Text
Summary
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a well-recognised disorder, first fully characterised in 2007. The long-term sequelae reported thus far include relapses with typical, as well as partial aspects of the well-defined neuropsychiatric syndrome. Rarely, isolated atypical symptoms (diplopia, ataxia and tremor) have been reported as relapse phenomenon. We report a case of a patient with a remote history of likely anti-NMDAR encephalitis with the longest follow-up reported in the literature to date (22 years). The relapse presentation was of a purely upper motor neuron syndrome with a primary lateral sclerosis-like picture.
- neurology
- immunology
- motor neurone disease
Statistics from Altmetric.com
Footnotes
Contributors MJ reviewed archived medical records, was the author of the initial draft and was involved in patients care as the advanced trainee of the team. WK was the primary neurologist involved in patient’s current outpatient and inpatient evaluation/management and the main editor of the manuscript. He was also involved in her original care in 1994. MN was involved in patients follow-up, care and editing of the manuscript. SS was involved in refining and editing of manuscript, contribution to discussion from the neuroimmunology perspective and reviewed previous case series on the topic.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.