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Rare disease
CASE REPORT
Mixed extragonadal germ cell tumour of the prostate
  1. Hugo Pontes Antunes1,
  2. Rui Almeida2,
  3. Vítor Sousa2,
  4. Arnaldo Figueiredo1
  1. 1 Department of Urology and Renal Transplantation, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal
  2. 2 Department of Pathology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal
  1. Correspondence to Dr Hugo Pontes Antunes, hugoantunes4{at}gmail.com

Summary

Extragonadal germ cell tumours (EGGCTs) originated in prostate are extremely rare, with <20 cases described in the literature. We report a case of a patient with a primary prostatic mixed EGGCT. A 47-year-old man presenting severe low urinary tract symptoms and signs of prostatic enlargement, with no malignancy suspicion, underwent transurethral resection of the prostate. The histopathological evaluation suggested the diagnosis of a retroperitoneal sarcoma. The patient underwent neoadjuvant chemotherapy and then was submitted to radical cystoprostatectomy. Histology revealed a mixed EGGCT of the prostate with yolk sac tumour and seminoma components. No testicular abnormalities were identified on the postoperative scrotal ultrasound. The patient went through four cycles of chemotherapy with bleomycin, etoposide and cisplatin. After 12 months of follow-up, the patient is alive and free of recurrence.

  • cancer intervention
  • urological cancer
  • pathology
  • prostate
  • urinary and genital tract disorders

https://doi.org/10.1136/bcr-2017-223603

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    Footnotes

    • Contributors HPA and RA: equally contributed to the paper, writing and gathering necessary data for its elaboration. VS and AF: reviewed the paper and approved the final version.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.