BMJ Case Reports 2018; doi:10.1136/bcr-2017-223539
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)

Selective internal radiation therapy (SIRT) with yttrium-90 microspheres for unresectable intrahepatic cholangiocarcinoma

  1. Jonathan Tibballs2
  1. 1General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia
  2. 2General Surgery, Sir Charles Gairdner Hospital, Nedlands, Australia
  1. Correspondence to Dr Vindya Abeysinghe, vindya1143{at}
  • Accepted 22 February 2018
  • Published 9 March 2018


Unresectableintrahepaticcholangiocarcinoma has a very poor prognosis despite various treatment options. The case presented describes the diagnostic challenges of a young pregnant woman with unresectable cholangiocarcinoma. The current treatment options for cholangiocarcinoma have limited evidence and high recurrence rate. Given the young age of this patient, selective internal radiotherapy was trialled with traditional chemotherapy with a clinically significant result. This case highlights the delays when diagnosing cholangiocarcinoma in younger patients and the possibility of selective internal radiation therapy in combination with chemotherapy as a potential first-line treatment for a complete response in unresectable disease.


  • Contributors Each author has contributed equally to this case report. VA conducted a literature search, second draft and obtained patient consent. SS completed the initial draft. LD completed the final draft and collaborated treatment. JT reviewed the details regarding treatment.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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