BMJ Case Reports 2018; doi:10.1136/bcr-2017-222937
  • Unusual association of diseases/symptoms

Reversible bioprosthetic valve thrombosis from eosinophilia

  1. Nitish Rai
  1. Department of Cardiology, Cardio-Thoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Professor S S Kothari, kothariss100{at}
  • Accepted 3 January 2018
  • Published 8 February 2018


A 31-year-old man with a mitral bioprosthetic valve presented with recent worsening of exertional dyspnoea 7 years after the mitral valve replacement. Evaluation revealed an increased gradient across the thickened mitral bioprosthetic valve leaflets. Marked eosinophilia was present and was considered as a putative cause for bioprosthetic valve thrombosis. The treatment with systemic corticosteroids and oral anticoagulation led to complete resolution of symptoms with significant decrease in mitral bioprosthetic valve gradient and leaflet thinning. The case is reported to highlight the fact that eosinophilia may cause reversible bioprosthetic valve thrombosis.


  • Contributors SSK has contributed to the diagnosis and treatment of the patient. SD and NR have contributed to the planning and reporting of the case under the guidance of SSK.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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