BMJ Case Reports 2018; doi:10.1136/bcr-2017-222693
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)

Non-surgical intervention for retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: treatment with ulipristal acetate

Editor's Choice
  1. Harold M P Pelikan
  1. Department of Obstetrics and Gynaecology, Haaglanden Medical Center, Den Haag, The Netherlands
  1. Correspondence to Dr Harold M P Pelikan, h.pelikan{at}
  • Accepted 13 December 2017
  • Published 3 January 2018


This case report describes a very rare coexistence of retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: benign metastasising leiomyoma (BML). Despite surgical treatment growth of multiple nodules in the lungs, omentum, mesenterium and retroperitoneum was observed by CT scan. We started off-label ulipristal acetate treatment with impressive results. The lesions on the CT scan disappeared, and the patient was asymptomatic after treatment.


  • Contributors Both authors equally contributed to the conception or design of the work, figure interpretation, critical revision of the article and final approval of the version to be published. KK was involved in the drafting of the article.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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