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CASE REPORT
Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis
  1. Mark Louis Siefring1,
  2. Doanh Lu1,
  3. J Christopher States2,
  4. Minh Van Hoang3
  1. 1Department of Dermatology, Stamford Skin Centre, Ho Chi Minh City, Vietnam
  2. 2Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA
  3. 3Department of Dermatology, University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam
  1. Correspondence to Dr Mark Louis Siefring, stamford.doctormark{at}gmail.com

Summary

We report a case of a 46-year-old Vietnamese man who developed widespread, numerous and concurrent cutaneous squamous cell carcinomas (SCCs) in non-sun exposed skin areas after taking a traditional medicine (TM) formulation for chronic plaque psoriasis. The SCC lesions began to develop within 12–15 months after beginning the arsenic-containing TM. The patient experienced both acute and chronic symptoms consistent with arsenic exposure. Laboratory investigation of a collected hair sample showed a significant arsenic level. The TM formulation used by the patient was tested and demonstrated an extremely high concentration of arsenic.

  • skin cancer
  • dermatology

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Footnotes

  • Contributors MLS: primary manuscript author, evaluated patient, performed excision of patients for squamous cell cancers, arranged with the aid of Nurse My Ton the acquisition of the arsenic-containing traditional medicine formulation that the patient used and arranged testing of the traditional medication for assessing the concentration of arsenic within the medication. DL: evaluation and assessment of the patient, provided ongoing care and evaluation to the patient, performed later biopsy for patient and excision of lesion of skin malignancy and edited manuscript in ongoing basis. JCS: toxicology and pharmacology, expertise within the field of arsenic toxicology and pathomechanisms of arsenic-induced carcinogenesis. He has had very significant involvement in manuscript editing and has been a primary Discussion section contributor. MVH: evaluation/assessment and initial treatment of the patient, excising the large two primary acral-located squamous cell carcinoma lesions, and followed postsurgical wound care after these lesions, diagnosed patient with arsenic-induced malignancies by hair sample analysis, provided initial data, involved in review of the manuscript and checking accuracy for the clinical care and diagnostic aspects.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.