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Rare disease
CASE REPORT
Central congenital hypothyroidism caused by maternal thyrotoxicosis
  1. Daphne Peeters1,2,
  2. Sandra van Gijlswijk3,
  3. Ralph W. Leunissen1,
  4. Danielle C.M. van der Kaay2
  1. 1Department of Pediatrics, Haaglanden Medisch Centrum (HMC), The Hague, The Netherlands
  2. 2Department of Pediatrics, Haga Hospital/Juliana Children’s Hospital, The Hague, Netherlands
  3. 3Department of Pediatrics, St Antonius Ziekenhuis, Woerden, The Netherlands
  1. Correspondence to Dr Danielle C.M. van der Kaay, d.vanderkaay{at}hagaziekenhuis.nl

Summary

Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves’ disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disruption of fetal hypothalamic-pituitary-thyroid axis maturation. In CCH, maternal thyroid disease should be considered.

  • endocrinology
  • paediatrics
  • neonatal health

https://doi.org/10.1136/bcr-2017-222620

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    Footnotes

    • Contributors All four authors were directly involved in the patient’s care. The first draft was written by DP, SvG, RL and DvdK, and DP critically reviewed the manuscript draft and approved it for final submission. DvdK was the paediatric endocrinologist who was consulted and who guided the writing process.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Parental/guardian consent obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.