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Rare disease
CASE REPORT
Two patients with localised hyperhidrosis of the hand based on functional and structural abnormalities of sweat glands
  1. Bjørn H Kristiansen1,
  2. Kim H Lindahl2,
  3. Kristine A U Pallesen1,
  4. Anette Bygum1
  1. 1Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark
  2. 2Department of Clinical Pathology, University Hospital of Odense, Odense, Denmark
  1. Correspondence to Bjørn H Kristiansen, bjkri11{at}student.sdu.dk

Summary

A 14-year-old girl and a 30-year-old woman presented with localised hyperhidrosis on the dorsal hand and wrist, respectively, provoked by different stimuli such as physical activity and minor trauma to the skin. The skin was seemingly normal in both patients where an iodine–starch test revealed a well-demarcated area of hyperhidrosis. Following histopathological examination, the diagnosis was unilateral localised hyperhidrosis in both cases; one with normal histology and one with a nevus sudoriferous. Both patients were successfully treated with botulinum toxin type A. The 30-year-old woman additionally used low-dose propantheline bromide periodically and experienced long-term remission on this therapy. Hyperhidrosis may embarrass and interfere with patients’ school and careers, and it is therefore important to tailor an effective individual treatment.

  • dermatology
  • skin
  • pathology

https://doi.org/10.1136/bcr-2017-222530

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    Footnotes

    • Contributors BHK was the main contributor to all aspects of planning and writing of the article, including clinical images. KHL contributed to the histopathological images and the description of these. KAUP contributed to writing the part regarding patient 2. AB contributed to planning and writing/editing all parts of the article. All of the authors certify that they will take public responsibility for the contents, have contributed substantially to the drafting and have approved the final version.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.