BMJ Case Reports 2018; doi:10.1136/bcr-2017-222302
  • Unusual presentation of more common disease/injury

Vitamin B12 deficiency: unusual cause of jaundice in an adolescent

  1. Manju Venkataramaiahyappa2
  1. 1Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  2. 2Department of Paediatrics, Melaka-Manipal Medical College, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India
  1. Correspondence to Dr Phalguna Kousika Katakam, phalguna.kousika{at}
  • Accepted 14 December 2017
  • Published 12 January 2018


Vitamin B12 deficiency in vegans is a known cause of megaloblastic anaemia. We report an adolescent girl who presented with jaundice and weight loss for 6 months secondary to vitamin B12 deficiency, leading to megaloblastic anaemia. Replacement with vitamin B12 reversed her symptoms, resulting in weight gain, and normalised her haemoglobin, red blood cell morphology, bilirubin levels and serum vitamin B12 levels.


  • Contributors PKK, APH and MV identified and came to the diagnosis and initiated the management. PKK initiated the idea of reporting such a rare presentation and was involved in the preparation of manuscript. APH has given her valuable inputs in preparation of the manuscript and had reviewed the same before submission.

  • Competing interests None declared.

  • Patient consent Guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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