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Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
CASE REPORT
Secondary mania following cancer chemotherapy with capecitabine
  1. Harshit Garg,
  2. Sathya Prakash,
  3. Koushik Sinha Deb,
  4. Rakesh Kumar Chadda
  1. Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Dr Koushik Sinha Deb, koushik.sinha.deb{at}gmail.com

Summary

Mania-like states occurring due to neurological, metabolic or toxic conditions, without a primary mood disorder have been reported in scientific literature as secondary mania. A major clinical problem in such situations often stems from the difficulty to understand if the mood disturbance is indeed secondary to an organic cause or a coincidental primary mood disorder. Chemotherapy regimens have been associated with multiple psychiatric complications, including psychosis, mania and anxiety. Capecitabine is implicated to be associated with encephalopathy whose clinical presentation often mimics that of psychosis. However, presentations with mania have not been reported until with the capecitabine and oxaliplatin combination chemotherapy regimen. In this report, we describe a case of secondary mania in a patient suffering from carcinoma colon on treatment with chemotherapy regimen of capecitabine and oxaliplatin.

  • malignant disease and immunosuppression
  • mood disorders (including depression)

https://doi.org/10.1136/bcr-2017-220995

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    Footnotes

    • Contributors The authors have jointly collected the data and drafted the case report and share the responsibility of accuracy of its contents. HG was responsible for compilation of the data, conducting relevant review of literature and preparing the draft proposal of the case report. SP edited the draft proposal, compiled the analysis and interpretation of review of literature and the discussion, highlighting the relevance of the case. KSD conceptualised the case and designed the report after critical review of the proposal, along with supervision of the work of previous two authors. RC is the team lead and supervised all the other authors in critically analysing and drafting the report to meet the desired excellence.

    • Funding The authors have not received any grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.