BMJ Case Reports 2017; doi:10.1136/bcr-2017-223092
  • Images in…

Artery of Percheron ischaemic stroke revealed by brain MRI DWI/ADC sequences

  1. Jacopo C. DiFrancesco
  1. Department of Neurology and Laboratory of Neurobiology, University of Milano-Bicocca, Monza, Italy
  1. Correspondence to Dr Jacopo C. DiFrancesco, jacopo.difrancesco{at}
  • Accepted 22 November 2017
  • Published 2 December 2017


A 71-year-old Caucasian female patient presented with acute onset of visual disturbance, gait difficulties and fluctuation of consciousness.

Her medical history included artery hypertension, previous cardiac valve replacement with mechanical prosthesis, in treatment with oral anticoagulant.

An emergency CT scan resulted negative for acute lesions, haematological exams were normal, international normalised ratio (INR) was >2.5. The EKG revealed high-frequency atrial fibrillation, not previously known.

At the neurological examination, the patient presented drowsiness, easily resolved by verbal stimulus, bilateral divergent diplopia, with eye movements possible only horizontally and severe postural instability with retropulsion.

On the day after the onset of neurological symptoms, the patient underwent brain MRI without gadolinium. Axial fluid attenuation inversion recovery (FLAIR) sequences revealed diffuse cerebral vasculopathy in the bilateral white matter without evidence of acute lesions (figure 1). Diffusion-weighted imaging (DWI) sequences revealed the presence of recent ischaemic lesions in the territory of the artery of Percheron (AOP), involving the bilateral ventral thalamus portion and paramedian midbrain, confirmed by apparent diffusion coefficient (ADC) sequences (figure 2). The diagnosis of acute ischaemic stroke of the AOP of cardioembolic origin was made and oral anticoagulant therapy was strengthened, with INR ranging from 3.0 to 3.5. Treatment with beta blocker bisoprolol 2.5 mg daily was started with reduction of heart rate frequency. During hospitalisation, her clinical conditions progressively ameliorated, with complete recovery of fluctuation of consciousness. On discharge, vertical visual deficit was still present, but partially reduced and deambulation was possible only with support.

Figure 1

Axial brain MRI fluid attenuation inversion recovery (FLAIR) sequence of the bilateral thalamic infarct area, without evidence of acute lesions.

Figure 2

Recent ischaemic lesions in the bilateral ventral thalamus portion and paramedian midbrain revealed by diffusion-weighted imaging (DWI) (A, B; arrows) and apparent diffusion coefficient (ADC) (C, D; arrows) brain MRI sequences.

The AOP is a possible rare anatomic variant of the posterior cerebral circulation. This is a perforating artery deriving from the posterior cerebral artery, which divides into two branches to ensure the arterial circulation of the paramedian bilateral portion of the thalamus and the rostral midbrain.1

The acute occlusion of the AOP is a rare event,1 2 which can result from arterial embolism, atherothrombosis or cardioembolism.3 It is characterised by a typical triad of symptoms with altered mental state (mainly drowsiness, coma and hypersomnolence), vertical gaze palsy and memory deterioration. Other phenotypic manifestations can include speech disorders (generally dysarthria or aphasia), hemiparesis of variable severity, movement asymmetry or cerebellar ataxia and defects of ocular motility.2 3

The peculiar clinical characteristics of the AOP infarction allow suspecting it precociously. However, other major clinical conditions as meningoencephalitis, epilepsy and metabolic or toxic processes must be excluded before in the process of differential diagnosis, with consequent delay in the identification and rapid treatment of the responsible cause.

Here we show that ordinary brain MRI T2/FLAIR sequences could fail to properly detect brain small lesions determined by the AOP occlusion. In this case, only the application of the DWI/ADC sequences allowed the identification of the ischaemic lesions, leading to the correct diagnosis and consequent treatment.

This case report supports the importance of including brain MRI DWI/ADC sequences in the suspicions of AOP ischaemic stroke, in order to facilitate an earlier diagnosis and the proper treatment.

Learning points

  • Artery of Percheron (AOP) ischaemic stroke has peculiar clinical characteristics that allow to suspect it. However, other clinical conditions must be excluded before reaching the correct diagnosis.

  • Ordinary brain MRI sequences (T1/T2) may fail to detect small ischaemic lesions, better identified by the application of diffusion-weighted imaging (DWI)/apparent diffusion coefficient (ADC) sequences.

  • Brain MRI DWI/ADC sequences should always be included in the clinical suspicions of AOP ischaemic stroke.


  • Contributors JCD dealt with conception and design of the work, acquisition, analysis or interpretation of data.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.


Responses to this article

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article