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Novel diagnostic procedure
CASE REPORT
Source estimation of epileptic activity using eLORETA kurtosis analysis
  1. Shunichiro Ikeda1,2,
  2. Ryouhei Ishii3,
  3. Leonides Canuet4,
  4. Roberto D Pascual-Marqui1
  1. 1Department of Neuropsychiatry, Kansai Medical University,, Osaka, Japan
  2. 2University Hospital of Psychiatry, University of Bern, Bern, Switzerland
  3. 3Department of Psychiatry and Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan
  4. 4UCM-UPM Centre for Biomedical Technology, Department of Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid,, Spain
  1. Correspondence to Dr Ryouhei Ishii, ishii{at}psy.med.osaka-u.ac.jp

Summary

Exact low-resolution brain electromagnetic tomography (eLORETA) is a technique for three-dimensional representation of the distribution of sources of electrical activity in the brain. Kurtosis analysis allows for identification of spiky activity in the brain. To evaluate the reliability of eLORETA kurtosis analysis, the results of the analysis were compared with those of equivalent current dipole (ECD) and synthetic aperture magnetometry (SAM) kurtosis analysis of magnetoencephalography (MEG) data in a patient with epilepsy with elementary visual seizures in a 6-year follow-up.

The results of electroencephalography (EEG) eLORETA kurtosis analysis indicative of a right superior temporal spike source partially overlapped with MEG ECD/SAM kurtosis results in all recordings, with a total overlapping at the end of the follow-up period. Overall findings suggest that eLORETA kurtosis analysis of EEG data may aid in the localisation of spike activity sources in patients with epilepsy.

  • clinical neurophysiology
  • epilepsy and seizures
  • psychiatry

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bcr-2017-222123

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    Footnotes

    • Contributors SI contributed as the first author to the paper and conducted EEG analysis as outlined in the paper. RI was as a part of the psychiatry team caring for the particular patient. LC was the neurological consultant leading in the care of this patient. RDP-M developed analysis software.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.