Article Text
Statistics from Altmetric.com
Description
A 54-year-old man was admitted to our hospital due to experiencing a sudden, severe pain in the right shoulder after mild exercise. He had been losing weight over the previous month and had noticed a lump near his right shoulder. A chest X-ray showed a lytic lesion in the lateral half of his right collarbone (figure 1A) with a cortical break and the presence of a soft-tissue component. A chest CT scan showed the destruction of the bone and a 10×8×7 cm mass associated with the pathological fracture of the collarbone (figure 1B). The diagnostic workup was completed with an abdominal CT scan, which showed a large hepatic tumour, an alpha-fetoprotein blood test level of 1468 ng/mL (normal range <10 ng/mL) and a fine-needle aspiration cytology, which yielded the final diagnosis of disseminated disease of a hepatocellular carcinoma. Cells showed both TTF-1 and hepatocyte antigen positivity, whereas CK7, CK20, CDX2 and p40 were negative.
Sorafenib 400 mg twice daily was then started, but the patient developed intense malaise and hepatotoxicity 4 weeks after the treatment was initiated. Gamma-glutamyl transpeptidase levels were 1178 U/L (normal range 5–45 U/L), alanine transaminase was 234 U/L (normal range 5–30 U/L), aspartate transaminase 156 U/L, lactate dehydrogenase was 656 U/L (normal range 180–380 U/L) and bilirubin levels increased up to 15 mg/dL. The treatment was discontinued, but the patient's condition worsened and he benefited from palliative care medicine. The patient passed away 5 months after the diagnosis.
Hepatocellular carcinoma is the most common type of liver cancer. Given this, screening is focused on regular determination of alpha-fetoprotein and abdominal ultrasound in patients with cirrhosis patients. In these patients, this tumour can occur in 5%–15% of cases.1 The most frequent site where hepatocellular carcinoma spreads is the portal vein, where this tumour can cause portal vein thrombosis. However, other less common metastasis locations are also possible, such as the lung, lymph nodes and bone. About 5%–7% of patients with hepatocellular carcinoma have bone metastases when the tumour is diagnosed.2
The clinical presentation in our patient was uncommon, as he did not have chronic viral hepatitis or cirrhosis. Furthermore, the first symptom was related to an uncommon spreading site, that is, the collarbone. The typical symptoms are related to chronic liver disease, such as ascites or jaundice. Other complications may arise due to the extension of the tumour to the portal vein. When these symptoms are not present, suspicion for hepatocellular carcinoma may be elusive.
Learning points
Underlying liver disease, such as chronic viral hepatitis or cirrhosis, is the main risk factor for the development of this tumour.
Since there are no pathognomonic symptoms, hepatocellular carcinoma may be diagnosed at a late stage, with a poor outcome.
Patients with chronic viral hepatitis or cirrhosis should undergo regular determination of alpha-fetoprotein and abdominal ultrasound for screening purposes.
Footnotes
Contributors RGC wrote the first draft, OVG helped in the translation into English and MRB and NRA made interesting suggestions.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.