Article Text
Unexpected outcome (positive or negative) including adverse drug reactions
CASE REPORT
Rare side effect of adjuvant ipilimumab after surgical resection of melanoma: Guillain-Barré syndrome
Summary
Guillain-Barré syndrome is a life-threatening neurological disorder that presents with rapid ascending paralysis and areflexia. Guillain-Barré syndrome is traditionally associated with infections from a gastrointestinal or respiratory tract source. We report the case of a 71-year-old man with melanoma who was treated with ipilimumab as adjuvant immunotherapy and subsequently developed Guillain-Barré syndrome. The diagnosis was made clinically through physical exam findings. He was successfully treated with a combination of intravenous immunoglobulin therapy and corticosteroids.
- unwanted effects / adverse reactions
- cancer intervention
- peripheral nerve disease
- skin cancer
- chemotherapy