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A 68-year-old man with medical history significant for hypertension and stroke was transferred to our hospital with new onset dysarthria, right face and arm weakness following left carotid stent deployed 24 hours before. The National Institutes of Health Stroke Scale at admission was 7. Head and neck CT angiographies (CTAs) were performed demonstrating in-stent thrombosis of the left carotid artery (figure 1A) and a CT perfusion showed no core infarct but a perfusion defect within the left middle cerebral artery (MCA) territory, as defined by a Tmax greater than 6 s, measuring 78.9 mL (figure 1B).
Decision was made to treat him conservatively by starting heparin gtt and blood pressure augmentation with norepinephrine for systolic blood pressure goal >160 mm Hg. Forty-eight hours after admission, the patient complained of severe headache associated with right-sided paraesthesias and right-sided motor focal seizure without impaired consciousness in the setting of blood pressure nearing 200 mm Hg. An emergent CT head was performed to rule out haemorrhage. The CTA demonstrated recanalisation of the left carotid artery (figure 2A) and a CT perfusion showed hyperperfusion in the left cerebrum, as defined by increased relative cerebral blood flow (CBF) and relative cerebral blood volume (CBV) along with decreased mean transit time (MTT) and reduced Tmax (figure 2B). Blood pressure was controlled to less than 130 mm Hg, protamine was given to reverse heparin and the patient was loaded on levetiracetam as a seizure prophylaxis measure. Sudden recanalisation of the carotid artery resulted in an increased and unregulated CBF leading to a cerebral hyperperfusion syndrome (CHS). Subsequent MRI demonstrated the old infarct lesion and new lacunar infarcts in the distribution of the left MCA (figure 3). The patient was stabilised and discharged to a rehabilitation facility. At 90-day clinical follow-up, the patient has a modified Rankin Scale of 4 and he is being taken care at a nursing home.
The%20CHS is a rare condition that can result after carotid endarterectomy or carotid artery stenting.1 Clinical presentation includes acute neurological deficits such as new onset headache, seizures, hemiparesis or intracerebral haemorrhage. Early detection of the CHS is paramount to administer an appropriate management and decrease the likelihood of cerebral injury.2 CT perfusion has been proposed as a predictive tool for CHS in patients receiving intervention for carotid stenosis,3 and it is suitable to provide evidence of hyperperfusion and guide medical treatment.
Learning points
Cerebral hyperperfusion syndrome is a rare phenomenon that occurs after a rapid revascularisation of the carotid artery and an unregulated increased of the cerebral blood flow.
CT perfusion is a suitable imaging tool to provide evidence of cerebral hyperperfusion and guide medical management.
Footnotes
Contributors PA-S and MSN were responsible for study concept and design. MSN contributed to acquisition of the data. All the authors were responsible for analysis and interpretation of the data. PA-S and MSN contributed to drafting of the manuscript. RH and MC contributed to critical revision of the manuscript for important intellectual content. All the authors were responsible for administrative, technical and material support. RH and MC contributed to study supervision.
Competing interests RH is a Consultant for Covidien, Stryker, Codman and MicroVention. The other authors have no personal, financial or institutional interest in any of the drugs, materials or devices described in this article.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.