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BMJ Case Reports 2017; doi:10.1136/bcr-2017-220686
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)
  • CASE REPORT

Successful downstaging of locally recurrent penile squamous cell carcinoma with neoadjuvant nanosomal docetaxel lipid suspension (NDLS) based regimen followed by curative surgery

Open Access
  1. Deepak Bunger2
  1. 1Department of Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India
  2. 2Department of Medical Affairs and Clinical Research, Intas Pharmaceuticals Limited, Ahmedabad, India
  1. Correspondence to Dr Sameer Gupta, sameerdr79{at}gmail.com
  • Accepted 25 October 2017
  • Published 12 November 2017

Summary

Penile squamous cell carcinoma (pSCC) is a relatively rare disease in Western world but is a significant health problem in developing countries like India. We report here a case of successful multimodality management of recurrent pSCC with pelvic lymphadenopathy in a 56-year-old male patient with poorly controlled diabetes. The patient presented with ulceroproliferative growth over the residual penile stump clinically involving root of penis and with right pelvic lymphadenopathy. The patient had a history of partial penectomy done elsewhere 20 months ago. In view of the comorbidities, locally recurrent disease and presence of right Iliac lymphadenopathy, the patient was treated with nanosomal docetaxel lipid suspension (NDLS), cisplatin and 5-fluorouracil (TPF regimen) in the neoadjuvant setting followed by staged surgical resection. This is the first case report showing successful treatment of recurrent pSCC with NDLS-based TPF regimen in the neoadjuvant setting followed by staged surgery in a patient with poorly controlled diabetes.

Footnotes

  • Contributors Planning SG, SSP; Conduct SG, SSP; Reporting SG, SSP; Design & Conception SG, SSP; Data acquisition SG, SSP; Manuscript preparation SG, SSP, DB; Manuscript editing SG, SSP, DB; Manuscript review SG, SSP, DB; Guarantor SG;

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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