BMJ Case Reports 2017; doi:10.1136/bcr-2017-220351
  • Images in…

Vedolizumab: a novel medical intervention in the treatment of primary sclerosing cholangitis

  1. Sarah Glover4
  1. 1Department of Internal Medicine, University of Florida, Gainesville, Florida, USA
  2. 2Department of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA
  3. 3Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
  4. 4Department of Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA
  1. Correspondence to Dr Donevan Westerveld, dwesterveld{at}
  • Accepted 27 April 2017
  • Published 13 May 2017


Primary sclerosing cholangitis (PSC) is an idiopathic and insidious cholestatic liver disease characterised by persistent inflammation of the biliary tree, leading to fibrosis and stricturing.1 Often associated with inflammatory bowel disease, pathogenesis may be related to activated intestinal T-cells expressing the integrin cell surface receptor α4β7. These T-cells are recruited to the liver parenchyma resulting in persistent biliary inflammation.1 Patients typically remain asymptomatic until a diagnosis is attained by detection of elevated liver enzymes.2 No effective medical management exists, and the progressive fibrotic nature of the disease usually results in the necessity of liver transplantation.

We present a case of a male …

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article