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BMJ Case Reports 2017; doi:10.1136/bcr-2017-220351
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Vedolizumab: a novel medical intervention in the treatment of primary sclerosing cholangitis

  1. Sarah Glover4
  1. 1Department of Internal Medicine, University of Florida, Gainesville, Florida, USA
  2. 2Department of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA
  3. 3Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
  4. 4Department of Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA
  1. Correspondence to Dr Donevan Westerveld, dwesterveld{at}ufl.edu
  • Accepted 27 April 2017
  • Published 13 May 2017

Description

Primary sclerosing cholangitis (PSC) is an idiopathic and insidious cholestatic liver disease characterised by persistent inflammation of the biliary tree, leading to fibrosis and stricturing.1 Often associated with inflammatory bowel disease, pathogenesis may be related to activated intestinal T-cells expressing the integrin cell surface receptor α4β7. These T-cells are recruited to the liver parenchyma resulting in persistent biliary inflammation.1 Patients typically remain asymptomatic until a diagnosis is attained by detection of elevated liver enzymes.2 No effective medical management exists, and the progressive fibrotic nature of the disease usually results in the necessity of liver transplantation.

We present a case of a male …

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