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  • TSH and PRL, side-effect markers in aripiprazole treatment: adjunctive aripiprazole-induced thyrotropin oversuppression in a young man with schizophrenia

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Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
CASE REPORT
TSH and PRL, side-effect markers in aripiprazole treatment: adjunctive aripiprazole-induced thyrotropin oversuppression in a young man with schizophrenia
  1. Hidenobu Ohta1,2,
  2. Satoru Inoue2,
  3. Koichiro Hara2,3,
  4. Akihiko Watanabe2,4
  1. 1Department of Psychophysiology, National Institute of Mental health, National Center of Neurology and Psychiatry, Kodaira, Japan
  2. 2Department of Psychiatry, Asai Hospital, Togane, Japan
  3. 3Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan
  4. 4Department of Psychology, Kawamura Gakuen Woman's University, Abiko, Japan
  1. Correspondence to Dr Koichiro Hara, koichiro.hara{at}nifty.com

Summary

A 26-year-old Japanese man was admitted to our unit with exacerbated paranoid schizophrenia. Prior to his admission, daily administration of olanzapine had been sufficient to maintain a partial remission of his schizophrenia, but due to an exacerbation of his delusions, he had then also been prescribed aripiprazole, which had been followed by no improvement in symptoms and a gradual further exacerbation of auditory delusions. Physical examinations, brain MRI and neurophysiological assessment were unremarkable. Blood analysis, however, revealed extremely low thyroid-stimulating hormone (TSH) and prolactin-releasing hormone (PRL) concentration. Interestingly, after aripiprazole discontinuation, he returned to partial remission with an increase in plasma TSH and PRL concentration.

  • psychiatry
  • drugs: psychiatry
  • psychotic disorders (incl schizophrenia)

https://doi.org/10.1136/bcr-2017-220192

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    Footnotes

    • Contributors All authors cared for the patient and wrote the report, which was reviewed by them.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.