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Rare disease
CASE REPORT
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the gallbladder and review of the literature
  1. Munenori Honda M.D.1,2,
  2. Yoki Furuta M.D., Ph.D.2,3,
  3. Hideaki Naoe M.D., Ph.D.3,
  4. Yutaka Sasaki M.D., Ph.D.3
  1. 1Department of Gastroenterology and Hepatology, Kumamoto General Hospital, Yatsushiro, Japan
  2. 2Department of Gastroenterology and Hepatology, Kokuho Minamata Shiritsu Sogo Iryo Center, Minamata, Japan
  3. 3Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
  1. Correspondence to Dr Yutaka Sasaki M.D., Ph.D., sasakiy{at}kumamoto-u.ac.jp

Summary

Mucosa-associated lymphoid tissue (MALT) lymphoma is rarely observed in the gallbladder, and its diagnosis before surgery is difficult. This report describes a case of primary MALT lymphoma of the gallbladder in an 80-year-old man. Imaging studies revealed a protruding lesion on the inside of the gallbladder, which led us to diagnose gallbladder carcinoma prior to the patient undergoing extended cholecystectomy. Microscopic examination of the resected specimen of the gallbladder demonstrated lymphoid follicles with atypical lymphocytes and the formation of lymphoepithelial lesions. These findings led to a final pathological diagnosis of primary MALT lymphoma of the gallbladder. The patient has been free of recurrence for 39 months after the surgery. Although precise diagnosis before the surgery was difficult in this case, preoperative examinations revealed a submucosal tumour-like lesion. MALT lymphomas should be considered when imaging findings are atypical for gallbladder carcinoma.

  • gastroenterology
  • pancreas and biliary tract

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bcr-2017-220161

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    Footnotes

    • Contributors MH performed the clinical examination and managed the patient and wrote the paper. YF performed the clinical examination and revised the manuscript. HN revised the manuscript. YS revised and conducted the manuscript. All authors discussed the results and implications and commented on the manuscript at all stages.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.