BMJ Case Reports 2017; doi:10.1136/bcr-2017-220084
  • Unexpected outcome (positive or negative) including adverse drug reactions

Internal carotid artery occlusion and stroke as a complication of cisplatin-based chemotherapy for metastatic testicular germ cell tumour

  1. Mohammed Azam
  1. SBH Health System, Internal Medicine, Bronx, New York, USA
  1. Correspondence to Dr Roberto Christian Cerrud-Rodriguez, robertocerrud{at}
  • Accepted 2 June 2017
  • Published 18 June 2017


Testicular tumours are the most common tumours in young men. Germ cell tumours (GCTs) account for 95% of all testicular cancers, and the non-seminomatous type (NSGCT) accounts for 50% of all GCTs. Cisplatin-based chemotherapy is curative in up to 90% of patients, but it is not without its inherent risks. Ischaemic stroke is a very uncommon, but severe complication of cisplatin-based chemotherapy. Strokes in young patients cause a disproportionately large economic impact by leaving victims disabled during their most productive years and strains the healthcare system with expensive hospital stays. We present a case of a young male patient with past medical history of metastatic NSGCT with the sudden onset of dysarthria, left hemiplegia and ipsilateral hemisensory loss 3 days after receiving cisplatin-based chemotherapy. Subsequent studies revealed a stroke involving the right middle cerebral artery territory secondary to an acute right internal carotid occlusion.


  • Contributors RCC-R, as first author, was in charge of performing the chart review, obtaining consent from the patient, and doing the initial literature review on the topic. He was also responsible for writing the drafts for the case report, and making any modifications required by the Institutional Review Board or the supervising attending physician. MGQ, as second author, was in charge of additional literature review, on obtaining additional sources for past medical records of the patient that could be relevant to our case report, and of obtaining authorisation from the radiology department to use the images presented in this case report. MA, as third author and attending physician, was in charge of the overall execution of the case report, verifying that all steps required by our Institutional Review Board were fulfilled, as well as proofreading of the initial versions of the manuscript and approving the final version of the submitted manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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