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Unusual association of diseases/symptoms
CASE REPORT
Sarcoidosis–lymphoma syndrome: a diagnostic dilemma
  1. Assad Oskuei1,
  2. Lisa Hicks2,
  3. Hasan Ghaffar3,
  4. Victor Hoffstein4
  1. 1Department of Pulmonary and Critical Care, New York University School of Medicine, New York, USA
  2. 2Department of Internal Medicine, University of Toronto, Toronto, Ontario, Canada
  3. 3Department of Pathology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
  4. 4Department of Respirology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
  1. Correspondence to Dr Assad Oskuei, assad.oskuei{at}nyumc.org

Summary

Sarcoidosis and lymphoma are generally thought of as being two mutually exclusive diseases that need to be considered in the differential diagnosis of patients with hilar/mediastianal lymphadenopathy. However, there are rare patients in whom both of these diseases coexist. These patients constitute a diagnostic challenge because their presentation (ie, clinical symptoms, imaging abnormalities and even pathology) may all be atypical when each individual disease is considered separately. In this report, we describe a patient who presented with such atypical features and was eventually diagnosed as having both sarcoidosis and a B-cell lymphoma with features of splenic marginal zone lymphoma (SMZL) simultaneously. To our knowledge, this is only the second reported case of SMZL and sarcoidosis in the same patient.

  • immunology
  • cancer
  • respiratory system
  • cancer intervention
  • pathology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bcr-2017-220065

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    Footnotes

    • Contributors AO is primary author of the paper. The manuscript was edited by HG and LH. VH is the main supervising attending on the case.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.