Article Text
Novel treatment (new drug/intervention; established drug/procedure in new situation)
CASE REPORT
Severe medication-induced peripheral neuropathy treated with topical doxepin cream in a paediatric patient with leukaemia
Summary
A 17-year-old female with recently relapsed acute lymphoblastic leukaemia and a treatment course complicated by rhinocerebral mucormycosis infection developed severe peripheral neuropathy during the treatment for mucormycosis infection. This was felt to be a medication side effect. Her peripheral neuropathy was refractory to many well-established treatments, but ultimately responded dramatically and consistently to a novel therapy, topical doxepin cream (5%). This case report is the first published report of the application of topical doxepin cream for treatment of peripheral neuropathy in a paediatric patient.
- Peripheral nerve disease
- Paediatric oncology
- Neurology (drugs and medicines)