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  • Severe medication-induced peripheral neuropathy treated with topical doxepin cream in a paediatric patient with leukaemia

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Novel treatment (new drug/intervention; established drug/procedure in new situation)
CASE REPORT
Severe medication-induced peripheral neuropathy treated with topical doxepin cream in a paediatric patient with leukaemia
  1. Zephyr D Dworsky1,
  2. Rebecca Bennett2,
  3. Jenny M Kim3,
  4. Dennis John Kuo3
  1. 1Pediatrics, University of California, San Diego, California, USA
  2. 2Acute/Chronic Pain Service, Rady Children's Hospital - San Diego, San Diego, CA, USA
  3. 3Pediatric Hematology-Oncology, University of California, San Diego, California, USA
  1. Correspondence to Dr Dennis John Kuo, dekuo{at}ucsd.edu, djkuo{at}rchsd.org

Summary

A 17-year-old female with recently relapsed acute lymphoblastic leukaemia and a treatment course complicated by rhinocerebral mucormycosis infection developed severe peripheral neuropathy during the treatment for mucormycosis infection. This was felt to be a medication side effect. Her peripheral neuropathy was refractory to many well-established treatments, but ultimately responded dramatically and consistently to a novel therapy, topical doxepin cream (5%). This case report is the first published report of the application of topical doxepin cream for treatment of peripheral neuropathy in a paediatric patient.

  • Peripheral nerve disease
  • Paediatric oncology
  • Neurology (drugs and medicines)

https://doi.org/10.1136/bcr-2017-219900

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    Footnotes

    • Contributors All the authors (ZD, RB, JMK, DJK) have cared for the patient and contributed to the conception, design, writing and editing of this manuscript. All the authors have reviewed the manuscript and agree to its content for submission.

    • Competing interests None declared.

    • Patient consent Consent obtained from guardian.

    • Provenance and peer review Not commissioned; externally peer reviewed.