BMJ Case Reports 2017; doi:10.1136/bcr-2017-219859

Postintervention acute opsoclonus myoclonus syndrome

  1. Josanne Aquilina3
  1. 1 Department of Neurosciences, Mater Dei Hospital, Attard, Malta
  2. 2 Department of Neuroscience, Mater Dei Hospital, Msida, Malta
  3. 3 Department of Neurology, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Dr Annelise Aquilina, annie.aquilina{at}
  • Accepted 5 April 2017
  • Published 21 April 2017


Opsoclonus myoclonus syndrome (OMS) is a rare, neurological condition affecting 1 in 10 000 000 people annually. Opsoclonus, defined as involuntary rapid, multivectorial oscillations of the eyes, together with ataxia and myoclonus are usually present. OMS may be paraneoplastic: often associated with occult neuroblastoma in childhood and with breast carcinoma or small cell lung carcinoma in adults. Other aetiologies include viral or toxic agents. The pathogenesis is thought to be immune mediated. A 37-year-old woman with previous inflammatory cranial mononeuropathies was admitted for elective dilatation and curettage (D&C). Immediately after she complained of left-sided paraesthesia and later became disoriented, with incoherent speech, inability to obey commands, opsoclonus of the eyes and myoclonic jerks. Investigations including onconeuronal antibodies, cerebrospinal fluid analysis, and imaging were normal. She was treated with intravenous methylprednisolone with rapid improvement. Previous surgeries with anaesthesia were uncomplicated. The anaesthetic agents used for the D&C were fentanyl and propofol.


  • Contributors AA wrote the case report with the guidance of the firm responsible for the patient's care. Resident specialist, neurology: ND. Consultant neurologist: JA.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article