BMJ Case Reports 2017; doi:10.1136/bcr-2017-219472
  • Unusual association of diseases/symptoms

Takotsubo cardiomyopathy and transient global amnesia: a shared aetiology

  1. Gary Gordon
  1. Department of Cardiology, Eastern Health, Victoria, Australia
  1. Correspondence to Dr Kevin Rajakariar, kevin.rajakariar{at}
  • Accepted 17 June 2017
  • Published 14 July 2017


Takotsubo cardiomyopathy (TTC) is associated with acute, reversible left ventricular (LV) dysfunction, while transient global amnesia (TGA) is a reversible disorder of the brain characterised by anterograde amnesia. We report an unusual case of TTC occurring concurrently in a patient with TGA, and propose that catecholamine surge induced cerebral venous congestion and cardiotoxicity is the shared aetiology that leads to the concurrent manifestation of these conditions. TTC and TGA are reversible disorders that can occur concurrently in a subset of patients due to a unifying aetiology, catecholamine excess, leading to pathophysiological changes within the brain and the myocardium.


  • Contributors JS and AK treated the patient and co-wrote the initial draft, with editing of the draft and figures by KR. Final draft and figures revised by GG.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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