BMJ Case Reports 2017; doi:10.1136/bcr-2017-219354
  • Unexpected outcome (positive or negative) including adverse drug reactions

Treatment of severe hypocalcaemia due to osteoblastic metastases in a patient with post-thyroidectomy hypoparathyroidism with 153Sm-EDTMP

Open Access
  1. Helen Gogas
  1. National and Kapodistrian University of Athens - Faculty of Medicine, , Athens, Greece
  1. Correspondence to Professor Helen Gogas, hgogas{at}
  • Accepted 4 May 2017
  • Published 16 May 2017


Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with 153Sm.


  • Contributors HG was the clinician responsible for the medical treatment of patient. IK, MK and EK were taking care of the patient during the hospitalization. EK and IK wrote the manuscript. All authors read, edited and approved the case report.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

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